Therapeutic implications of the mGluR theory of fragile X mental retardation

被引:105
作者
Bear, MF
机构
[1] MIT, Picower Ctr Learning & Memory, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
关键词
anxiety disorder; autism; cognitive development; dendritic protein synthesis; long-term depression; metabotropic glutamate receptors; seizure disorder;
D O I
10.1111/j.1601-183X.2005.00135.x
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Evidence is reviewed that the consequences of group 1 metabotropic glutamate receptor (Gp1 mGluR) activation are exaggerated in the absence of the fragile X mental retardation protein, likely reflecting altered dendritic protein synthesis. Abnormal mGluR signaling could be responsible for remarkably diverse psychiatric and neurological symptoms in fragile X syndrome, including delayed cognitive development, seizures, anxiety, movement disorders and obesity.
引用
收藏
页码:393 / 398
页数:6
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