West Nile virus population genetics and evolution

被引:60
作者
Pesko, Kendra N. [1 ]
Ebel, Gregory D. [1 ]
机构
[1] Univ New Mexico, Sch Med, Dept Pathol, Albuquerque, NM 87131 USA
关键词
West Nile virus; Molecular epidemiology; Population genetics; Pathogenesis; Fitness; AMINO-ACID SUBSTITUTION; ENVELOPE PROTEIN GLYCOSYLATION; NEW-YORK-STATE; UNITED-STATES; LINEAGE; PHYLOGENETIC ANALYSIS; MOLECULAR EVOLUTION; ENCEPHALITIS-VIRUS; SUBURBAN CHICAGO; MUTANT SPECTRUM;
D O I
10.1016/j.meegid.2011.11.014
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
West Nile virus (WNV) (Flaviviridae: Flavivirus) is transmitted from mosquitoes to birds, but can cause fatal encephalitis in infected humans. Since its introduction into North America in New York in 1999, it has spread throughout the western hemisphere. Multiple outbreaks have also occurred in Europe over the last 20 years. This review highlights recent efforts to understand how host pressures impact viral population genetics, genotypic and phenotypic changes which have occurred in the WNV genome as it adapts to this novel environment, and molecular epidemiology of WNV worldwide. Future research directions are also discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:181 / 190
页数:10
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