The evolution of synthetic oral drug properties

被引：101

作者：

Proudfoot, JR ^{[1
]}

机构：

[1] Boehringer Ingelheim Pharmaceut Inc, Ridgefield, CT 06877 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.bmcl.2004.12.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An analysis of the properties of 1791 synthetic, oral drugs approved and/or marketed since 1937 demonstrates that the median molecular weight of oral drugs has increased substantially over the past 60 years. Fewer than 5% of approved/marketed oral drugs have more than 4-H bond donors and just 2% have MW > 500 and >3 H-bond donors. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1087 / 1090

页数：4

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