A balance of lipid-sensing mechanisms in the brain and liver

被引：52

作者：

Caspi, Liora

Wang, Penny Y. T.

Lam, Tony K. T. ^{[1
]}

机构：

[1] Univ Hlth Network, Toronto Gen Hosp, Res Inst, Toronto, ON M5G 1L7, Canada

[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[3] Univ Toronto, Dept Med, Toronto, ON M5S 1A8, Canada

来源：

CELL METABOLISM | 2007年 / 6卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2007.07.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.

引用

收藏

页码：99 / 104

页数：6

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