New tricks for an old dogma:: Riboswitches as cis-only regulatory systems

被引：6

作者：

Stormo, GD ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

来源：

MOLECULAR CELL | 2003年 / 11卷 / 06期

关键词：

D O I：

10.1016/S1097-2765(03)00240-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Riboswitches are mRNAs that can act as direct sensors of small molecules to control their own expression. In the May 30, 2003, issue of Cell, Mandal et al. show that cis elements in mRNAs involved in purine metabolism measure the effector molecule concentration with sensitivity and specificity, and control expression of adjacent genes. Analysis of several recently discovered riboswitches suggests that this may be a common, efficient mechanism for regulating the synthesis of proteins required for the production of important metabolites.

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页码：1419 / 1420

页数：2

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