Successful antifungal combination therapy with voriconazole and caspofungin

被引：25

作者：

Schuster, F

Moeller, C

Schmid, I

Graubner, UB

Kammer, B

Belohradsky, BH

Führer, M

机构：

[1] Univ Munich, Div Pediat Hematol Oncol, D-80337 Munich, Germany

[2] Univ Munich, Div Pediat Radiol, Munich, Germany

[3] Univ Munich, Div Pediat Radiol, Munich, Germany

来源：

PEDIATRIC BLOOD & CANCER | 2005年 / 44卷 / 07期

关键词：

antifungal therapy; caspofungin; invasive pulmonary aspergillosis; stem cell transplantation; voriconazole;

D O I：

10.1002/pbc.20302

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 12-year-old boy in third remission of an acute lymphoblastic leukaemia developed infection of lung and paranasal sinuses with Aspergillus flavus in neutropenia. Because of the high risk of leukaemia-relapse bone marrow transplantation (BMT) from a matched unrelated donor was carried out despite invasive pulmonary aspergillosis (IPA). It is the first reported patient with IPA, who was successfully treated by the antifungal combination therapy with voriconazole and caspofungin therapy during myeloablative BMT. Despite 6 weeks of aplasia, a dramatic decrease of lesions highly suggestive of aspergillosis was observed after BMT. Since discharge-oral voriconazole monotherapy has been continued. (c) 2005 Wiley-Liss, Inc.

引用

页码：682 / 685

页数：4

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