Synthesis of 5-fluorouracil-imprinted polymers with multiple hydrogen bonding interactions

被引：37

作者：

Kugimiya, A ^{[1
]}

Mukawa, T ^{[1
]}

Takeuchi, T ^{[1
]}

机构：

[1] Hiroshima City Univ, Fac Informat Sci, Lab Synth Biochem, Asaminami Ku, Hiroshima 7313194, Japan

来源：

ANALYST | 2001年 / 126卷 / 06期

关键词：

D O I：

10.1039/b010056k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for 5-FU derivatives. By using both functional monomers simultaneously, the affinity and separation for 5-FU were improved.

引用

页码：772 / 774

页数：3

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