The chromosomal passenger complex: One for all and all for one

被引:78
作者
Ruchaud, Sandrine [1 ]
Carmena, Mar [1 ]
Earnshaw, William C. [1 ]
机构
[1] Univ Edinburgh, Inst Cell Biol, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland
基金
英国惠康基金;
关键词
D O I
10.1016/j.cell.2007.10.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The chromosomal passenger complex - composed of Aurora B kinase and its regulatory subunits INCENP, Survivin, and Borealin - modulates multiple events during mitosis. In this issue, Jeyaprakash al. (2007) report the crystal structure of the regulatory subunit complex and reveal how interactions between these proteins promote the targeting and function of the chromosomal passenger complex during mitosis.
引用
收藏
页码:230 / 231
页数:2
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