A genome screen for multiple sclerosis in Italian families

被引：60

作者：

Broadley, S

Sawcer, S

D'Alfonso, S

Hensiek, A

Coraddu, F

Gray, J

Roxburgh, R

Clayton, D

Buttinelli, C

Quattrone, A

Trojano, M

Massacesi, L

Compston, A

机构：

[1] Univ Florence, Dip Sci Neurol & Psichiat, I-50134 Florence, Italy

[2] Univ Cambridge, Addenbrookes Hosp, Neurol Unit, Cambridge CB2 2QQ, England

[3] Univ Piermonte Orientale A Avogadro, Dept Med Sci, Chair Human Genet, Novara, Italy

[4] Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England

[5] Univ La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

[6] Univ Catanzaro, Dept Med Sci, Catanzaro, Italy

[7] CNR, Inst Expt Med & Biotechnol, I-00185 Rome, Italy

[8] Univ Bari, Dept Neurol & Psychiat Sci, I-70121 Bari, Italy

[9] Univ Florence, Dept Neurol & Psychait Sci, I-50121 Florence, Italy

来源：

GENES AND IMMUNITY | 2001年 / 2卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

multiple sclerosis; linkage; genome screen; genetic susceptibility;

D O I：

10.1038/sj.gene.6363758

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.

引用

页码：205 / 210

页数：6

共 27 条

[1] A metric map of humans: 23,500 loci in 850 bands
Collins, A
Frezal, J
Teague, J
Morton, NE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14771 - 14775
[2] Compston A., 1998, MCALPINES MULTIPLE S, P283
[3] COMPSTON DAS, 1990, J ROY COLL PHYS LOND, V24, P207
[4] Linkage analysis of multiple sclerosis with candidate region markers in Sardinian and Continental Italian families
D'Alfonso, S
Nisticò, L
Zavattari, P
Marrosu, MG
Murru, R
Lai, M
Massacesi, L
Ballerini, C
Gestri, D
Salvetti, M
Ristori, G
Bomprezzi, R
Trojanò, M
Liguori, M
Gambi, D
Quattrone, A
Fruci, D
Cucca, F
Richiardi, PM
Tosi, R
[J]. EUROPEAN JOURNAL OF HUMAN GENETICS, 1999, 7 (03) : 377 - 385
[5] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES
DAVIES, JL
KAWAGUCHI, Y
BENNETT, ST
COPEMAN, JB
CORDELL, HJ
PRITCHARD, LE
REED, PW
GOUGH, SCL
JENKINS, SC
PALMER, SM
BALFOUR, KM
ROWE, BR
FARRALL, M
BARNETT, AH
BAIN, SC
TODD, JA
[J]. NATURE, 1994, 371 (6493) : 130 - 136
[6] A comprehensive genetic map of the human genome based on 5,264 microsatellites
Dib, C
Faure, S
Fizames, C
Samson, D
Drouot, N
Vignal, A
Millasseau, P
Marc, S
Hazan, J
Seboun, E
Lathrop, M
Gyapay, G
Morissette, J
Weissenbach, J
[J]. NATURE, 1996, 380 (6570) : 152 - 154
[7] DIEHL SR, 1990, AM J HUM GENET, V47, pA177
[8] Genetics of multiple sclerosis
Dyment, DA
Sadnovich, AD
Ebers, GC
[J]. HUMAN MOLECULAR GENETICS, 1997, 6 (10) : 1693 - 1698
[9] A full genome search in multiple sclerosis
Ebers, GC
Kukay, K
Bulman, DE
Sadovnick, AD
Rice, G
Anderson, C
Armstrong, H
Cousin, K
Bell, RB
Hader, W
Paty, DW
Hashimoto, S
Oger, J
Duquette, P
Warren, S
Gray, T
OConnor, P
Nath, A
Auty, A
Metz, L
Francis, G
Paulseth, JE
Murray, TJ
PrysePhillips, W
Nelson, R
Freedman, M
Brunet, D
Bouchard, JP
Hinds, D
Risch, N
[J]. NATURE GENETICS, 1996, 13 (04) : 472 - 476
[10] THE 1993-94 GENETHON HUMAN GENETIC-LINKAGE MAP
GYAPAY, G
MORISSETTE, J
VIGNAL, A
DIB, C
FIZAMES, C
MILLASSEAU, P
MARC, S
BERNARDI, G
LATHROP, M
WEISSENBACH, J
[J]. NATURE GENETICS, 1994, 7 (02) : 246 - 339

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