Elucidation of the mechanism of the 1,6-cuprate addition to acceptor-substituted enynes through 13C kinetic isotope effects:: Experimental and theoretical studies

被引：47

作者：

Mori, S ^{[1
]}

Uerdingen, M

Krause, N

Morokuma, K

机构：

[1] Ibaraki Univ, Fac Sci, Mito, Ibaraki 3108512, Japan

[2] Univ Dortmund, D-44221 Dortmund, Germany

[3] Emory Univ, Cherry L Emerson Ctr Sci Computat, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 30期

关键词：

allenes; cuprates; density functional calculations; isotope effects; Michael addition;

D O I：

10.1002/anie.200462976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A combination of experimental and theoretical studies of 13C kinetic isotope effects have led to a comprehensive mechanistic picture of the 1,6-cuprate addition to acceptor-substituted enynes. In the rate-determining step, the new bond is formed from the triple bond of the substrate to the incoming alkyl group (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：4715 / 4719

页数：5

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