The relationship of salivary and cord blood cortisol in preterm infants

被引：16

作者：

Chou, I-Ching ^{[2
]}

Lien, Han-Chung ^{[3
]}

Lin, Hung-Chih ^{[4
]}

Fu, Jachih J. C. ^{[5
,6
]}

Kao, Chia-Hung ^{[7
]}

Tsai, Chang-Hai ^{[8
]}

Lin, Pao-Hsuan ^{[9
]}

Tsai, Fuu-Jen ^{[1
,4
,10
,11
]}

机构：

[1] China Med Univ Hosp, Dept Pediat, Childrens Med Ctr, Taichung, Taiwan

[2] China Med Univ, Grad Inst Integrated Med, Chinese Med Coll, Taichung, Taiwan

[3] Taichung Vet Gen Hosp, Dept Gastroenterol, Taichung, Taiwan

[4] China Med Univ, Chinese Med Coll, Inst China Med Sci, Taichung, Taiwan

[5] Dept Ind Management, Yunlin, Taiwan

[6] Grad Sch Ind Engn & Management, Yunlin, Taiwan

[7] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan

[8] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan

[9] China Med Univ, Ctr Biostat, Taichung, Taiwan

[10] China Med Univ Hosp, Dept Med Genet Pediat & Med Res, Taichung, Taiwan

[11] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan

来源：

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM | 2011年 / 24卷 / 1-2期

关键词：

cortisol; preterm; saliva; stress; SERUM CORTISOL; AXIS FUNCTION; DEXAMETHASONE; FETAL; BETAMETHASONE; HORMONES; CORTICOSTEROIDS; EXPOSURE; DELIVERY; PLASMA;

D O I：

10.1515/JPEM.2011.119

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Recent studies reveal that salivary cortisol measurements accurately reflect blood cortisol levels in older children and adults; yet, the relationship between the two values in premature infants has not been established. This study explores the use of salivary cortisol as an accurate measure of adrenal steroid concentrations in premature infants to provide a reliable and less invasive tool for investigating hormonal stress response. Premature infants (n = 51) were recruited, with saliva and blood collected immediately after birth, and cortisol levels measured by radioimmunoassay. A linear relationship emerged between cord plasma and salivary cortisol values in the 102 paired samples [(salivary cortisol) = 0.546 + 0.192 x (plasma cortisol), r = 0.481 and p = 0.0003]. Findings demonstrated that salivary and plasma cortisol levels were correlated in premature infants. This information will be useful in future studies that assess use of salivary cortisol to evaluate neonatal stress axis function.

引用

页码：85 / 88

页数：4

共 24 条

[1]

ALKALAY AL, 1990, PEDIATRICS, V86, P204

[2]

[Anonymous], 1995, J AM MED ASS, V273, P413

[3]

Correlation between plasma and salivary cortisol levels in preterm infants [J].