Role of the I-SK protein in the I-minK channel complex

被引：38

作者：

Busch, AE ^{[1
]}

Suessbrich, H ^{[1
]}

机构：

[1] INST PHYSIOL 1,D-72076 TUBINGEN,GERMANY

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1997年 / 18卷 / 01期

关键词：

D O I：

10.1016/S0165-6147(96)01016-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The I-SK (also called minK) protein, although it is structurally unrelated to any other ion channel subunit, induces slowly activating, voltage-dependent Kt channels (I-minK) in Xenopus oocytes or HEK293 cells. The quaternary structure of the I-minK channel complex has long remained a mystery, but recent studies suggest an interaction of the I-SK protein with a traditional K+ channel subunit, identified in man as K(V)LQT1. It is unclear at this point what the mechanism of this interaction is, or whether the I-SK protein may also interact with other ion channel subunits. However, there is an abundance of information regarding the role and regulation of the I-SK protein in the I-minK channel complex, discussed in this review by Andreas Busch and Hartmut Suessbrich. The I-SK protein is expressed in different tissues, where I-minK activation may have distinct net effects on cell function. This fact makes I-minK an excellent target for pharmacological agents.

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页码：26 / 29

页数：4

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