Analgesic effect of dioclenol and dioflorin isolated from Dioclea grandiflora

被引：11

作者：

Almeida, RN

Navarro, DS

Almeida, ER

Majetich, G

Bhattacharyya, J

机构：

[1] Univ Fed Paraiba, Lab Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil

[2] Univ Georgia, Dept Chem, Athens, GA 30602 USA

来源：

PHARMACEUTICAL BIOLOGY | 2000年 / 38卷 / 05期

关键词：

analgesic activity; Dioclea grandiflora; dioflorin; dioclenol; CNS activity;

D O I：

10.1076/phbi.38.5.394.5971

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The analgesic activity of dioflorin and dioclenol, two constituents of Dioclea grandiflora Mart., has been studied in mice. It was found that dioclenol (10 mg/kg, i.p.) and dioclenol (10 mg/kg, i.p.) were effective in the acetic acid-induced writhing and tail immersion tests. These observations suggest that dioflorin and dioclenol possesses central antinociceptive activity.

引用

页码：394 / 395

页数：2

共 6 条

[1]

Almeida R. N., 1996, Fitoterapia, V67, P334

[2]

BATISTA JS, 1993, THESIS U FEDERAL PAR, P3

[3]

Dioclenol, a minor flavanonol from the root-bark of Dioclea grandiflora [J].