Enhanced expression of manganese superoxide dismutase mRNA and increased TNF alpha mRNA expression by gastric mucosa in gastric cancer

被引：36

作者：

Izutani, R ^{[1
]}

Katoh, M ^{[1
]}

Asano, S ^{[1
]}

Ohyanagi, H ^{[1
]}

Hirose, K ^{[1
]}

机构：

[1] KUREHA CHEM IND CO,BIOCHEM RES LABS,SHINJUKU KU,TOKYO 160,JAPAN

来源：

WORLD JOURNAL OF SURGERY | 1996年 / 20卷 / 02期

关键词：

D O I：

10.1007/s002689900035

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Manganese superoxide dismutase (Mn-SOD), a mitochondrial enzyme, is a cytokine-regulated acute-phase protein that protects cells from free radicals. The current investigations examined the in vivo regulation of the expression of Mn-SOD mRNA and tumor necrosis factor alpha (TNF alpha) mRNA in gastric carcinoma tissue. The expression of these transcripts in breast carcinoma tissue also was examined because breast cancer is a much more TNF-sensitive tumor than gastric cancer. TNF alpha mRNA was markedly increased in gastric carcinoma tissue (p < 0.005). There were significantly higher levels of Mn-SOD mRNA in gastric carcinoma tissue than in noncancerous tissue (p < 0.0001). The level of Mn-SOD mRNA in gastric carcinoma tissue was higher than that in breast carcinoma tissue (p < 0.005). Up-regulation of Mn-SOD mRNA in gastric carcinoma tissue most likely serves as a protective mechanism against superoxide radicals and TNF cytotoxicity.

引用

页码：228 / 233

页数：6

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