Synthesis of functionalized α-amino-phosphine oxides and -phosphonates by addition of amines and aminoesters to 4-phosphinyl- and 4-phosphonyl-1,2-diaza-1,3-butadienes

被引：37

作者：

Palacios, F ^{[1
]}

Aparicio, D ^{[1
]}

López, Y ^{[1
]}

de los Santos, JM ^{[1
]}

机构：

[1] Univ Basque Country, Fac Farm, Dept Quim Organ 1, Vitoria 01080, Spain

来源：

TETRAHEDRON | 2005年 / 61卷 / 11期

关键词：

alpha-amino-phosphine oxides; alpha-amino-phosphonates; 4-phosphinyl-1,2-diaza-1,3-butadienes; 4-phosphonyl-1,2-diaza-1,3-butadienes; hydrazones; Michael addition;

D O I：

10.1016/j.tet.2005.01.081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,2-Diaza-1,3-butadienes derived from phosphine oxides and phosphonates and with optically active substituents on N-1 and C-3 are obtained by 1,4-elimination from chlorohydrazonoalkyl-phosphine oxides and -phosphonates in the presence of bases. Michael addition (1,4-addition) of ammonia, aliphatic and aromatic amines and aminoesters to these azo-alkenes gives functionalized alpha-amino-phosphine oxides and -phosphonates. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2815 / 2830

页数：16

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