Regioselective synthesis of 2-arylpropionic esters by palladium-catalyzed hydroesterification of styrene derivatives in molten salt media

被引：86

作者：

Zim, D ^{[1
]}

de Souza, RF ^{[1
]}

Dupont, J ^{[1
]}

Monteiro, AL ^{[1
]}

机构：

[1] Univ Fed Rio Grande Sul, Inst Quim, BR-91501970 Porto Alegre, RS, Brazil

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 39期

关键词：

hydroesterification; palladium and compounds; antiinflammatory compounds; molten salts;

D O I：

10.1016/S0040-4039(98)01551-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The palladium-catalyzed hydroesterification of styrene derivatives is performed in a two-phase system composed of 1-n-butyl-3-methylimidazoliumtetrafluoroborate salt (ionic phase) and isopropanol/cyclohexane (organic phase). Very high regioselectivities in 2-arylpropionic esters (greater than or equal to 99.5%) are obtained using a catalytic system composed of PdCl2(PhCN)(2), (+)-neomenthyldiphenylphosphine (NMDPP) and p-toluenesulfonic acid under mild reaction conditions (10 atm and 70 degrees C). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7071 / 7074

页数：4

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