共 30 条
Regulation of Raf through phosphorylation and N terminus-C terminus interaction
被引:77
作者:

Chong, HR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

Guan, KL
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机构:
Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
机构:
[1] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Inst Gerontol, Ann Arbor, MI 48109 USA
关键词:
D O I:
10.1074/jbc.M212803200
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Raf kinase is a key component in regulating the MAPK pathway. B-Raf has been reported as an oncogene and is mutated in 60% of human melanomas. The main focus of Raf regulation studies has been on phosphorylation, dephosphorylation, and scaffolding proteins; however, Raf also has its own auto-regulatory domain. Removal of the N-terminal regulatory domain, initially discovered in the viral Raf oncogene (v-Raf), results in a kinase domain with high basal activity independent of Ras activation. In this report, we show that activating phosphorylations are still required for activity of the truncated C-terminal kinase domain (called 22W). The interaction between the N-terminal regulatory domain and the C-terminal kinase domain is disrupted by activated Ras. Mutations in the Ras binding domain, cysteine-rich domain, or S259A do not affect the inhibition of 22W by the N-terminal domain. When phosphomimetic residues are substituted at the activating sites (DDED) in 22W, this results in a higher basal activity that is no longer inhibited by expression of the N-terminal domain, although binding to the N-terminal domain still occurs. Although the interaction between 22W/DDED and the N-terminal domain may be in a different conformation, the interaction is still disrupted by activated Ras. These data demonstrate that N-terminal domain binding to the kinase domain inhibits the activity of the kinase domain. However, this inhibition is relieved when the C-terminal kinase domain is activated by phosphorylation.
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页码:36269 / 36276
页数:8
相关论文
共 30 条
[1]
STRUCTURE AND BIOLOGICAL-ACTIVITY OF HUMAN HOMOLOGS OF THE RAF MIL ONCOGENE
[J].
BONNER, TI
;
KERBY, SB
;
SUTRAVE, P
;
GUNNELL, MA
;
MARK, G
;
RAPP, UR
.
MOLECULAR AND CELLULAR BIOLOGY,
1985, 5 (06)
:1400-1407

BONNER, TI
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205

KERBY, SB
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205

SUTRAVE, P
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205

GUNNELL, MA
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205

MARK, G
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205

RAPP, UR
论文数: 0 引用数: 0
h-index: 0
机构: NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20205
[2]
Positive and negative regulation of Raf kinase activity and function by phosphorylation
[J].
Chong, H
;
Lee, J
;
Guan, KL
.
EMBO JOURNAL,
2001, 20 (14)
:3716-3727

Chong, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

Lee, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA

Guan, KL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Biol Chem, Ann Arbor, MI 48109 USA
[3]
14-3-3 zeta negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain
[J].
Clark, GJ
;
Drugan, JK
;
Rossmann, KL
;
Carpenter, JW
;
RogersGraham, K
;
Fu, H
;
Der, CJ
;
Campbell, SL
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1997, 272 (34)
:20990-20993

Clark, GJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Drugan, JK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Rossmann, KL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Carpenter, JW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

RogersGraham, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Fu, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Der, CJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA

Campbell, SL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV N CAROLINA, LINEBERGER COMPREHENS CANC CTR, DEPT BIOCHEM & BIOPHYS, CHAPEL HILL, NC 27599 USA
[4]
Autoregulation of the Raf-1 serine/threonine kinase
[J].
Cutler, RE
;
Stephens, RM
;
Saracino, MR
;
Morrison, DK
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (16)
:9214-9219

Cutler, RE
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA

Stephens, RM
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA

Saracino, MR
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA

Morrison, DK
论文数: 0 引用数: 0
h-index: 0
机构:
NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mol Basis Carcinogenesis Lab, Frederick, MD 21702 USA
[5]
Mutations of the BRAF gene in human cancer
[J].
Davies, H
;
Bignell, GR
;
Cox, C
;
Stephens, P
;
Edkins, S
;
Clegg, S
;
Teague, J
;
Woffendin, H
;
Garnett, MJ
;
Bottomley, W
;
Davis, N
;
Dicks, N
;
Ewing, R
;
Floyd, Y
;
Gray, K
;
Hall, S
;
Hawes, R
;
Hughes, J
;
Kosmidou, V
;
Menzies, A
;
Mould, C
;
Parker, A
;
Stevens, C
;
Watt, S
;
Hooper, S
;
Wilson, R
;
Jayatilake, H
;
Gusterson, BA
;
Cooper, C
;
Shipley, J
;
Hargrave, D
;
Pritchard-Jones, K
;
Maitland, N
;
Chenevix-Trench, G
;
Riggins, GJ
;
Bigner, DD
;
Palmieri, G
;
Cossu, A
;
Flanagan, A
;
Nicholson, A
;
Ho, JWC
;
Leung, SY
;
Yuen, ST
;
Weber, BL
;
Siegler, HF
;
Darrow, TL
;
Paterson, H
;
Marais, R
;
Marshall, CJ
;
Wooster, R
.
NATURE,
2002, 417 (6892)
:949-954

Davies, H
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Bignell, GR
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Cox, C
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Stephens, P
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Edkins, S
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Clegg, S
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Teague, J
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Woffendin, H
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Garnett, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Bottomley, W
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Davis, N
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Dicks, N
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Ewing, R
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Floyd, Y
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Gray, K
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Hall, S
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Hawes, R
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Hughes, J
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Kosmidou, V
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Menzies, A
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Mould, C
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Parker, A
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Stevens, C
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Watt, S
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Hooper, S
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Wilson, R
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Jayatilake, H
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Gusterson, BA
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Cooper, C
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Shipley, J
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Hargrave, D
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Pritchard-Jones, K
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Maitland, N
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Chenevix-Trench, G
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Riggins, GJ
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Bigner, DD
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Palmieri, G
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Cossu, A
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Flanagan, A
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Nicholson, A
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Ho, JWC
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Leung, SY
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Yuen, ST
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Weber, BL
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Siegler, HF
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Darrow, TL
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Paterson, H
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Marais, R
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Marshall, CJ
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England

Wooster, R
论文数: 0 引用数: 0
h-index: 0
机构: Wellcome Trust Sanger Inst, Canc Genome Project, Hinxton CB10 1SA, England
[6]
REVERSAL OF RAF-1 ACTIVATION BY PURIFIED AND MEMBRANE-ASSOCIATED PROTEIN PHOSPHATASES
[J].
DENT, P
;
JELINEK, T
;
MORRISON, DK
;
WEBER, MJ
;
STURGILL, TW
.
SCIENCE,
1995, 268 (5219)
:1902-1906

DENT, P
论文数: 0 引用数: 0
h-index: 0
机构: UNIV VIRGINIA, HOWARD HUGHES MED INST, CHARLOTTESVILLE, VA 22908 USA

JELINEK, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV VIRGINIA, HOWARD HUGHES MED INST, CHARLOTTESVILLE, VA 22908 USA

MORRISON, DK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV VIRGINIA, HOWARD HUGHES MED INST, CHARLOTTESVILLE, VA 22908 USA

WEBER, MJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV VIRGINIA, HOWARD HUGHES MED INST, CHARLOTTESVILLE, VA 22908 USA

STURGILL, TW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV VIRGINIA, HOWARD HUGHES MED INST, CHARLOTTESVILLE, VA 22908 USA
[7]
Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
[J].
Dhillon, AS
;
Pollock, C
;
Steen, H
;
Shaw, PE
;
Mischak, H
;
Kolch, W
.
MOLECULAR AND CELLULAR BIOLOGY,
2002, 22 (10)
:3237-3246

Dhillon, AS
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

Pollock, C
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

Steen, H
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

Shaw, PE
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

Mischak, H
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

论文数: 引用数:
h-index:
机构:
[8]
Regulation of Raf-1 activation and signalling by dephosphorylation
[J].
Dhillon, AS
;
Meikle, S
;
Yazici, Z
;
Eulitz, M
;
Kolch, W
.
EMBO JOURNAL,
2002, 21 (1-2)
:64-71

Dhillon, AS
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, CRC, Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

Meikle, S
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, CRC, Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

Yazici, Z
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, CRC, Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

Eulitz, M
论文数: 0 引用数: 0
h-index: 0
机构: Beatson Inst Canc Res, CRC, Beatson Labs, Glasgow G61 1BD, Lanark, Scotland

论文数: 引用数:
h-index:
机构:
[9]
MUTATIONAL ACTIVATION OF C-RAF-1 AND DEFINITION OF THE MINIMAL TRANSFORMING SEQUENCE
[J].
HEIDECKER, G
;
HULEIHEL, M
;
CLEVELAND, JL
;
KOLCH, W
;
BECK, TW
;
LLOYD, P
;
PAWSON, T
;
RAPP, UR
.
MOLECULAR AND CELLULAR BIOLOGY,
1990, 10 (06)
:2503-2512

HEIDECKER, G
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

HULEIHEL, M
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

CLEVELAND, JL
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

KOLCH, W
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

BECK, TW
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

LLOYD, P
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

PAWSON, T
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA

RAPP, UR
论文数: 0 引用数: 0
h-index: 0
机构: NCI, FREDERICK CANC RES FACIL, VIRAL CARCINOGENESIS LAB, VIRAL PATHOL SECT, FREDERICK, MD 21701 USA
[10]
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
[J].
Jaumot, M
;
Hancock, JF
.
ONCOGENE,
2001, 20 (30)
:3949-3958

Jaumot, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Sch Med, Dept Pathol, Expt Oncol Lab, Brisbane, Qld 4006, Australia Univ Queensland, Sch Med, Dept Pathol, Expt Oncol Lab, Brisbane, Qld 4006, Australia

Hancock, JF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Queensland, Sch Med, Dept Pathol, Expt Oncol Lab, Brisbane, Qld 4006, Australia Univ Queensland, Sch Med, Dept Pathol, Expt Oncol Lab, Brisbane, Qld 4006, Australia