Synthesis of α-heterosubstituted glycine derivatives from dihaloethanamides

被引：24

作者：

Bailey, PD ^{[1
]}

Baker, SR

Boa, AN

Clayson, J

Rosair, GM

机构：

[1] Heriot Watt Univ, Dept Chem, Edinburgh EH14 4AS, Midlothian, Scotland

[2] Eli Lilly & Co, Windlesham GU20 6PH, Surrey, England

[3] Univ Hull, Dept Chem, Hull HU6 7RX, N Humberside, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 42期

基金：

英国工程与自然科学研究理事会;

关键词：

amino acids and derivatives; peptide analogues/mimetics;

D O I：

10.1016/S0040-4039(98)01658-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A range of protected a-heterosubstituted analogues of glycine were synthesised from starting materials of the type CHFX-CONHR [X = Cl, Br, I; R = CH2Ph, (S)-CHMePh]; the final products included derivatives of glycine possessing N, O, F or S in the alpha-position, and the first example of a free alpha-fluoro-alpha-amino acid (alpha-fluorobetaine) whose structure was confirmed by X-ray crystal structure determination. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7755 / 7758

页数：4

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