Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: Design of potent and specific 3,9-diazaspiro[5.5]undecanes

被引：12

作者：

Smyth, MS

Rose, J

Mehrotra, MM

Heath, J

Ruhter, G

Schotten, T

Seroogy, J

Volkots, D

Pandey, A

Scarborough, RM ^{[1
]}

机构：

[1] COR Therapeut Inc, Dept Med & Biol Chem, S San Francisco, CA 94080 USA

[2] Lilly Res Labs, Hamburg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(01)00215-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological activity of novel glycoprotein IIb-IIIa antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus an described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as central template for nonpeptide RGD mimics. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1289 / 1292

页数：4

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