Epidemics of gastroenteritis during 2006 were associated with the spread of norovirus GII.4 variants 2006a and 2006b

被引：148

作者：

Tu, Elise T. -V. ^{[1
,3
]}

Bull, Rowena A. ^{[1
,3
]}

Greening, Gail E. ^{[6
]}

Hewitt, Joanne

Lyon, Michael J. ^{[4
]}

Marshall, John A. ^{[5
]}

McIver, Christopher J. ^{[1
,2
,3
]}

Rawlinson, William D. ^{[1
,2
,3
]}

White, Peter A. ^{[1
]}

机构：

[1] Univ New S Wales, Fac Sci, Sch Biotechnol & Biomol Studies, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Fac Sci, Sch Med Sci, Sydney, NSW 2052, Australia

[3] Prince Wales Hosp, Dept Microbiol, SESIAHS, Div Virol, Sydney, NSW, Australia

[4] Queensland Hlth Sci Serv, Publ Hlth Virol, Brisbane, Qld, Australia

[5] Victoria Infect Dis Reference Lab, Melbourne, Vic, Australia

[6] Kenepuru Sci Ctr, Inst Environm Sci & Res, Porirua, New Zealand

来源：

CLINICAL INFECTIOUS DISEASES | 2008年 / 46卷 / 03期

关键词：

D O I：

10.1086/525259

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Acute gastroenteritis is commonly associated with norovirus genogroup II (GII) infection. Norovirus GII has 17 classified genotypes (GII.1-GII.17), but only 1 norovirus genotype (GII. 4) is associated with global epidemics of gastroenteritis. In 2006, an increase in global norovirus activity was observed. Methods. During the period from December 2005 through August 2006, a total of 231 fecal samples were obtained from patients with acute gastroenteritis from Australia and New Zealand. Norovirus RNA was amplified and sequenced to determine norovirus genotype and relatedness to known epidemic norovirus GII. 4 variants. Results. Two GII. 4 variants, designated 2006a and 2006b, were identified in 61.8% and 11.3%, respectively, of the 186 cases investigated. Norovirus 2006a and 2006b have also been implicated as the predominant causes of norovirus-associated gastroenteritis across Europe in 2006. Conclusions. The global increase in norovirus-associated gastroenteritis in 2006 was linked to the emergence of 2 novel GII. 4 variants, 2006a and 2006b.

引用

页码：413 / 420

页数：8

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