Smad4 (DPC4) - a potent tumour suppressor?

被引:35
作者
Duff, EK [1 ]
Clarke, AR [1 ]
机构
[1] Univ Edinburgh, Sch Med, Dept Pathol, Edinburgh EH8 9AG, Midlothian, Scotland
关键词
Smad4; DPC4; tumour suppressor; cancer;
D O I
10.1038/bjc.1998.731
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The recently described family of Smad molecules are essential mediators of transforming growth factor beta (TGF-beta) signalling. To date, seven members of this family have been identified, each of which plays a specific and separate role in mediating TGF-beta superfamily gene transcription. At least two different Smads, Smad2 and Smad4 (DPC4), have been implicated in human cancer and appear to have tumour-suppressor functions. Loss of function of Smad4 is most strongly associated with human pancreatic and colorectal malignancy. Furthermore, work from several different groups has suggested associations between Smad4 loss and malignancy in a number of other tissues. Here, we present a review of the current state of the literature implicating the central Smad mediator, Smad4, in the development of cancer.
引用
收藏
页码:1615 / 1619
页数:5
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