Protein destruction: Adapting roles for Cks proteins

被引：88

作者：

Harper, JW ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 11期

关键词：

D O I：

10.1016/S0960-9822(01)00253-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cks1, a subunit of cyclin-dependent kinases, has now been identified as an essential cofactor in the ubiquitination of the Cdk inhibitor p27 by the SCFSkp2 ubiquitin ligase. This activity, which can be independent of Cdk binding, links Cks to positive growth control pathways regulating the G1/S transition and to cancer.

引用

页码：R431 / R435

页数：5

共 27 条

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