Poly(hydroxyethyl methacrylate)-based macroporous hydrogels with disulfide cross-linker

被引：53

作者：

Andac, M. ^{[3
]}

Plieva, F. M. ^{[2
,3
]}

Denizli, A.

Galaev, I. Yu. ^{[1
]}

Mattiasson, B. ^{[1
]}

机构：

[1] Lund Univ, Dept Biotechnol, SE-22100 Lund, Sweden

[2] IDEON, Protista Biotechnol AB, SE-22370 Lund, Sweden

[3] Hacettepe Univ, Dept Chem, Fac Sci, Div Biochem, TR-06532 Ankara, Turkey

来源：

MACROMOLECULAR CHEMISTRY AND PHYSICS | 2008年 / 209卷 / 06期

关键词：

D O I：

10.1002/macp.200700467

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Biodegradable supermacroporous PHEMA cryogels were produced by combining two cross-linkers, poly(ethylene glycol) diacrylate and a newly developed disulfide water soluble crosslinker, N,N'-bis(methacryloyl)-L-cystine. The biodegradable PHEMA cryogels were prepared with gel fraction yields up to 70% and were characterized by highly interconnected pores of micrometer size and good mechanical stability. When subjected to reductive agents like DTT, the biodegradable PHEMA cryogels disintegrated into small pieces. The rate of disintegration was controlled by the crosslinking density in the cryogels and the DTT concentration.

引用

页码：577 / 584

页数：8

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