A genomic duplication in Arabidopsis thaliana contains a sequence similar to the human gene coding for SAP130

被引：2

作者：

Casacuberta, E

Puigdomènech, P

Monfort, A

机构：

[1] CSIC, Cid, Inst Biol Mol Barcelona, Dept Mol Genet, ES-08034 Barcelona, Spain

[2] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

PLANT PHYSIOLOGY AND BIOCHEMISTRY | 2001年 / 39卷 / 7-8期

关键词：

Arabidopsis thaliana; genomic duplication; spliceosomal associated proteins;

D O I：

10.1016/S0981-9428(01)01280-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The Arabidopsis thaliana gene orthologue to human SAP 130 is contained in a perfect genomic duplication of 4.3 kb. The 1217-aa AtSAP130 protein is 73 % similar to the human gene that is also present in the Caenorhabditis elegans, Drosophila melanogaster and Sacharomyces pombe genomes. The duplicated sequence includes the coding region, two introns, a 32-bp segment in the 5' non-coding region and 420 bp of 3' non-coding region that contains an intron. Sequence homology with ESTs suggests that at least one of the gene copies is transcribed. The presence of the 4.5-kb inverted duplicated sequence has been verified in thirteen ecotypes of A. thaliana. Size variation was detected relative to the Columbia ecotype and corresponds to the deletion of a 3' non-coding region that is flanked by a 110-bp tandem repeat. The AtSAP130 duplication appears to be a recent event in the Arabidopsis species evolution. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：565 / 573

页数：9

共 31 条

[1] repE - The Dictyostelium homolog of the human xeroderma pigmentosum group E gene is developmentally regulated and contains a leucine zipper motif [J].