Functional Characterization of Tn4401, a Tn3-Based Transposon Involved in blaKPC Gene Mobilization

被引：150

作者：

Cuzon, Gaelle

Naas, Thierry ^{[1
]}

Nordmann, Patrice

机构：

[1] Hop Bicetre, Assistance Publ Hop Paris, Serv Bacteriol Virol, INSERM Emerging Resistance Antibiot U914, F-94275 Le Kremlin Bicetre, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 11期

关键词：

SPECTRUM-BETA-LACTAMASE; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; NEW-YORK; KPC; RESISTANCE; EXPRESSION; EMERGENCE; PLASMIDS; FAMILY;

D O I：

10.1128/AAC.05202-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The carbapenemase gene bla(KPC), which is rapidly spreading worldwide, is located on a Tn3-based transposon, Tn4401. In a transposition-conjugation assay, Tn4401 was able to mobilize bla(KPC-2) gene at a frequency of 4.4 x 10(-6)/recipient cell. A 5-bp target site duplication was evidenced upon each insertion without target site specificity. This study demonstrated that Tn4401 is an active transposon capable of mobilizing bla(KPC) genes at high frequency.

引用

页码：5370 / 5373

页数：4

共 26 条

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