Hydroxychloroquine: From Malaria to Autoimmunity

被引：493

作者：

Ben-Zvi, Ilan ^{[1
,3
]}

Kivity, Shaye ^{[1
,4
]}

Langevitz, Pnina ^{[1
]}

Shoenfeld, Yehuda ^{[1
,2
]}

机构：

[1] Chaim Sheba Med Ctr, Zabludowicz Ctr Autoimmune Dis, Rheumatol Unit, IL-52621 Tel Hashomer, Israel

[2] Chaim Sheba Med Ctr, Dept Internal Med B, IL-52621 Tel Hashomer, Israel

[3] Chaim Sheba Med Ctr, Dept Internal Med F, IL-52621 Tel Hashomer, Israel

[4] Chaim Sheba Med Ctr, Dept Internal Med A&C, IL-52621 Tel Hashomer, Israel

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2012年 / 42卷 / 02期

关键词：

Chloroquine; Hydroxychloroquine; Antimalarial; Novel; Therapy; Lupus; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHRONIC LYMPHOCYTIC-LEUKEMIA; DEPENDENT DIABETES-MELLITUS; VERSUS-HOST-DISEASE; GROWTH IN-VITRO; RHEUMATOID-ARTHRITIS; ANTIPHOSPHOLIPID ANTIBODIES; CELL-GROWTH; T-CELLS; ANTIMALARIAL-DRUGS;

D O I：

10.1007/s12016-010-8243-x

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Quinine was first recognized as a potent antimalarial agent hundreds of years ago. Since then, the beneficial effects of quinine and its more advanced synthetic forms, chloroquine and hydroxychloroquine, have been increasingly recognized in a myriad of other diseases in addition to malaria. In recent years, antimalarials were shown to have various immunomodulatory effects, and currently have an established role in the management of rheumatic diseases, such as systemic lupus erythematosus and rheumatoid arthritis, skin diseases, and in the treatment of chronic Q fever. Lately, additional metabolic, cardiovascular, antithrombotic, and antineoplastic effects of antimalarials were shown. In this review, we discuss the known various immunomodulatory mechanisms of antimalarials and the current evidence for their beneficial effects in various diseases and in potential novel applications.

引用

页码：145 / 153

页数：9

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