Clamp loader structure predicts the architecture of DNA polymerase III holoenzyme and RFC

被引：77

作者：

O'Donnell, M

Jeruzalmi, D

Kuriyan, J

机构：

[1] Rockefeller Univ, New York, NY 10021 USA

[2] Howard Hughes Med Inst, New York, NY 10021 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 22期

关键词：

D O I：

10.1016/S0960-9822(01)00559-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent determinations of the crystal structure of the Escherichia coli gamma complex and delta-beta assembly have shed light on the bacterial clamp loading reaction. In this review, we discuss the structures of delta-beta and the gamma (3)delta delta ' complex and its mechanism of action as a clamp loader of the E. coli beta sliding clamp. We also expand upon the implications of the structural findings to the structure and function of the eukaryotic clamp loader, RFC, and the structure of E. coli DNA polymerase III holoenzyme.

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收藏

页码：R935 / R946

页数：12

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