Phosphorelay signalling: New tricks for an ancient pathway

被引：11

作者：

Brown, JM ^{[1
]}

Firtel, RA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, Ctr Mol Genet, La Jolla, CA 92093 USA

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0960-9822(07)00417-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

'Two-component' phosphorelay systems, once thought to be used exclusively by prokaryotes, have in the past few years been shown to exist in eukaryotes. A two-component system in Dictyostelium has now been shown to modulate protein kinase A, a key regulator of multicellular development in this organism.

引用

页码：R662 / R665

页数：4

共 14 条

[1] A NEW CLASS OF RAPIDLY DEVELOPING MUTANTS IN DICTYOSTELIUM-DISCOIDEUM - IMPLICATIONS FOR CYCLIC-AMP METABOLISM AND CELL-DIFFERENTIATION [J].

ABE, K ;

YANAGISAWA, K .

DEVELOPMENTAL BIOLOGY, 1983, 95 (01) :200-210

[2] Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum [J].

Anjard, C ;

Zeng, CJ ;

Loomis, WF ;

Nellen, W .

DEVELOPMENTAL BIOLOGY, 1998, 193 (02) :146-155

[3] Signal transduction via the multi-step phosphorelay: Not necessarily a road less traveled [J].

Appleby, JL ;

Parkinson, JS ;

Bourret, RB .

CELL, 1996, 86 (06) :845-848

[4] EUKARYOTES HAVE 2-COMPONENT SIGNAL TRANSDUCERS [J].

CHANG, C ;

MEYEROWITZ, EM .

RESEARCH IN MICROBIOLOGY, 1994, 145 (5-6) :481-486

[5] Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium [J].

Chang, WT ;

Thomason, PA ;

Gross, JD ;

Newell, PC .

EMBO JOURNAL, 1998, 17 (10) :2809-2816

[6] INTEGRATION OF SIGNALING INFORMATION IN CONTROLLING CELL-FATE DECISIONS IN DICTYOSTELIUM [J].

FIRTEL, RA .

GENES & DEVELOPMENT, 1995, 9 (12) :1427-1444

[7]

Loomis WF, 1997, J CELL SCI, V110, P1141

[8] COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS [J].

PARKINSON, JS ;

KOFOID, EC .

ANNUAL REVIEW OF GENETICS, 1992, 26 :71-112

[9] Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK [J].

Posas, F ;

Saito, H .

SCIENCE, 1997, 276 (5319) :1702-1705

[10] Dual role of cAMP during Dictyostelium development [J].

Reymond, CD ;

Schaap, P ;

Veron, M ;

Williams, JG .

EXPERIENTIA, 1995, 51 (12) :1166-1174

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