Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

被引：481

作者：

Badve, Sunil ^{[1
]}

Dabbs, David J. ^{[2
]}

Schnitt, Stuart J. ^{[3
,4
]}

Baehner, Frederick L. ^{[5
]}

Decker, Thomas ^{[6
]}

Eusebi, Vincenzo ^{[7
]}

Fox, Stephen B. ^{[8
]}

Ichihara, Shu ^{[9
]}

Jacquemier, Jocelyne ^{[10
]}

Lakhani, Sunil R. ^{[11
,12
]}

Palacios, Jose ^{[13
]}

Rakha, Emad A. ^{[14
]}

Richardson, Andrea L. ^{[15
]}

Schmitt, Fernando C. ^{[16
]}

Tan, Puay-Hoon ^{[17
]}

Tse, Gary M. ^{[18
]}

Weigelt, Britta ^{[19
]}

Ellis, Ian O. ^{[14
]}

Reis-Filho, Jorge S. ^{[20
]}

机构：

[1] Indiana Univ, Dept Pathol & Internal Med, Clarian Pathol Lab, Indianapolis, IN 46204 USA

[2] Univ Pittsburgh, Dept Pathol, Med Ctr, Pittsburgh, PA USA

[3] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Univ Calif San Francisco, Dept Anat Pathol, San Francisco, CA 94143 USA

[6] Univ Hosp Munster, Reference Ctr Munster, Gerhard Domagk Inst Pathol, Munster, Germany

[7] Univ ASL Osped Bellaria, Sez Anat Istol & Citol Patol M Malpighi, Bologna, Italy

[8] Peter MacCallum Canc Ctr, Dept Pathol, Melbourne, Vic, Australia

[9] Nagoya Med Ctr, Dept Pathol, Nagoya, Aichi, Japan

[10] Inst J Paoli I Calmettes, Unite Anat & Cytol Pathol, F-13009 Marseille, France

[11] Univ Queensland, Clin Res Ctr, Sch Med & Pathol Queensland, Brisbane, Qld, Australia

[12] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia

[13] Hosp Univ Virgen Rocio, Serv Anat Patol, Seville, Spain

[14] Univ Nottingham, Nottingham City Hosp NHS Trust, Dept Histopathol, Nottingham NG7 2RD, England

[15] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[16] Univ Porto, Fac Med, Inst Mol Pathol & Immunol IPATIMUP, P-4100 Oporto, Portugal

[17] Singapore Gen Hosp, Dept Pathol, Singapore 0316, Singapore

[18] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, Hong Kong, Hong Kong, Peoples R China

[19] Canc Res UK London Res Inst, Signal Transduct Lab, London, England

[20] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

MODERN PATHOLOGY | 2011年 / 24卷 / 02期

关键词：

basal-like; breast cancer; definition; practical review; triple-negative; CARCINOMA IN-SITU; COMPARATIVE GENOMIC HYBRIDIZATION; ALPHA-B-CRYSTALLIN; MICROGLANDULAR ADENOSIS; ESTROGEN-RECEPTOR; DUCTAL CARCINOMA; MOLECULAR CLASSIFICATION; EPITHELIAL PHENOTYPE; COPY NUMBER; TUMOR SIZE;

D O I：

10.1038/modpathol.2010.200

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for 'basal-like cancer', which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists. Modern Pathology (2011) 24, 157-167; doi:10.1038/modpathol.2010.200; published online 12 November 2010

引用

页码：157 / 167

页数：11

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