Prefrontal cortical dysfunction in abstinent cocaine abusers

被引：197

作者：

Bolla, K

Ernst, M

Kiehl, K

Mouratidis, M

Eldreth, D

Contoreggi, C

Matochik, J

Kurian, V

Cadet, J

Kimes, A

Funderburk, F

London, E

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21224 USA

[2] NIMH, Mood & Anxiety Disorders Program, New Haven, CT USA

[3] Hartford Hosp, Inst Living, New Haven, CT USA

[4] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[5] NIDA, Brain Imaging Ctr, Intramural Res Program, Bethesda, MD 20892 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Brain Res Inst, Los Angeles, CA USA

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 2004年 / 16卷 / 04期

关键词：

D O I：

10.1176/appi.neuropsych.16.4.456

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The anterior cingulate cortex (ACC) and lateral prefrontal (LPFC) cortex are brain regions important to executive cognitive functions (ECF). We determined ACC and LPFC function in 23-day abstinent cocaine abusers using positron emission tomography (PET (H2O)-O-15) during performance of a modified version of the Stroop Task. Cocaine abusers showed less activation than non-drug-using comparison subjects in the left ACC and the right LPFC and greater activation in the right ACC. Average amount of cocaine used per week was negatively correlated with activity in the rostral ACC and right LPFC. Disruption of ECF in substance abusers could interfere with attempts to stop drug use and undermine treatment. Since impairment in ECF may be a common feature of various neuropsychiatric disorders, these findings have applicability beyond the neurobiology of addiction.

引用

页码：456 / 464

页数：9

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