Determination and Tissue Distribution Comparisons of Atractylodin after Oral Administration of Crude and Processed Atractylodes Rhizome

被引：12

作者：

Liu, Yang-Zhi ^{[1
]}

Liu, Yu-Qiang ^{[1
]}

Jia, Rui ^{[1
]}

Li, Jun ^{[2
]}

Chang, Xiao-Wen ^{[1
]}

Xu, Chen-Xi ^{[1
]}

Cai, Qian ^{[1
]}

机构：

[1] Liaoning Univ Tradit Chinese Med, Dept Med, Dalian 116600, Peoples R China

[2] Dalian Inst Drug Control, Dept Med, Dalian, Peoples R China

来源：

PHARMACOGNOSY MAGAZINE | 2017年 / 13卷 / 51期

基金：

中国国家自然科学基金;

关键词：

Atractylodin; Atractylodis rhizoma; crude and processed; tissue distribution;

D O I：

10.4103/pm.pm_394_16

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Background: Atractylodis rhizoma is one of the most often used drugs in traditional Chinese medicine. Stir frying with wheat bran is the most common processing method. To clarify the principle of processing, an experiment was carried out to compare the tissue distribution of typical constituent after oral administration of raw A. rhizoma and processed ones. Objective: To compare the tissues distribution of atractylodin after oral administration of raw and processed A. rhizoma and clarify the processing principle of A. rhizoma. Materials and Methods: High-performance liquid chromatogram with ultraviolet detection was developed and validated for the determination of atractylodin in rat tissues. Results: The atractylodin in raw and processed A. rhizoma was distributed in all tissues involved in this study. Conclusions: The concentration of atractylodin in it is the highest in the stomach and small intestine.

引用

页码：413 / 417

页数：5

共 13 条

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[2]

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[3]

Chinese Pharmacopoeia Committee, 2010, PHARM COMM PHARM PEO

[4]

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