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Snare-mediated membrane fusion

被引：902
作者：
Chen, YA [1 ]
Scheller, RH
机构：
[1] Stanford Univ, Howard Hughes Med Inst, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA
[2] Renovis Inc, Oakland, CA 94609 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 02期
关键词：
D O I：
10.1038/35052017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SNARE proteins have been proposed to mediate all intracellular membrane fusion events. There are over 30 SNARE family members in mammalian cells and each is found in a distinct subcellular compartment. it is likely that SNAREs encode aspects of membrane transport specificity but the mechanism by which this specificity is achieved remains controversial. Functional studies have provided exciting insights into how SNARE proteins interact with each other to generate the driving force needed to fuse lipid bilayers.
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页码：98 / 106
页数：9
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