Enhanced penicillin production by oligosaccharides from batch cultures of Penicillium chrysogenum in stirred-tank reactors

被引：31

作者：

Ariyo, B ^{[1
]}

Tamerler, C ^{[1
]}

Bucke, C ^{[1
]}

Keshavarz, T ^{[1
]}

机构：

[1] Univ Westminster, Dept Biotechnol, Fungal Biotechnol Grp, London W1M 8JS, England

来源：

FEMS MICROBIOLOGY LETTERS | 1998年 / 166卷 / 01期

关键词：

Penicillium chrysogenum fermentation; oligosaccharide elicitor; penicillin G enhancement;

D O I：

10.1016/S0378-1097(98)00326-7

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Alginate and galactomannan-derived oligosaccharides enhanced the production of penicillin G when added to stirred tank reactor cultures of Penicillium chrysogenum. The addition of oligomannuronate and oligoguluronate blocks increased penicillin G yield by 47% and 49%, respectively. The effect of mannan oligosaccharides was found to be more pronounced with 69% higher yield than the control cultures. The maximum increase in the average specific productivity of the oligosaccharide augmented cultures was 55% after addition of mannan oligosaccharides. In addition, a difference was observed in all cases in the accumulation pattern of the intermediate of penicillin biosynthesis, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：165 / 170

页数：6

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