Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKH938-II.: Structure elucidation

被引：34

作者：

Fukuda, T

Tomoda, H

Omura, S

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[4] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 05期

关键词：

citridones; phenylfuropyridone; Penicillium; anti-infective; azole potentiator;

D O I：

10.1038/ja.2005.39

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The structures of citridones A, B, B' and C, new potentiators of miconazole activity against Candida albicans produced by Penicillium sp. FKI-1938, were elucidated by various spectroscopic analyses including UV, NMR, and MS and degradation experiments. Although citridones B and B' were isolated as a mixture, each structure was also elucidated, indicating that they exist in equilibrium of hemiacetal epimerization. Citridones A, B and B' have a similar phenylfuropyridone moiety.

引用

页码：315 / 321

页数：7

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