The use of MatriDerm® in early excision and simultaneous autologous skin grafting in burns -: A pilot study

The application of dermal substitutes in deep partial and full-thickness burn wounds in a two-stage procedure prior to skin grafting has become increasingly popular. Synchronous application of dermal substitutes and skin graft has not yet been established as a standard procedure. In a consecutive study 20 wounds in 10 patients with severe burns (age 49.5 +/- 16.2 years; TBSA 45.6 +/- 14.5%) were treated with either simultaneous transplantation of Matriderm(R), a bovine based collagen 1, 111, V and elastin hydrolysate based dermal substitute and split-thickness skin grafting (STSG), or STSG alone after appropriate excision of the burn wound. The study was designed as a prospective intra-individual comparative study. After I week all wounds were assessed for the percentage of autograft survival. Autograft survival was not altered by simultaneous application of a dermal matrix (p = 0.015). Skin elasticity was measured after 3-4 months with the Vancouver Burn Skin Score (VBSS). The VBSS demonstrated a significant increase of elasticity in the group with dermal substitutes (p = 0.04) as compared with non-substituted wounds for sheet autograft, but not for meshed autograft (p = 0.24). From this pilot study it can be concluded that simultaneous application of a dermal matrix is safe and feasible, yielding significantly better results with respect to skin elasticity. Skin elasticity was considerably improved by the collagen/elastin dermal substitute Matriderm(R) in combination with sheet autograft. (C) 2007 Elsevier Ltd and ISBI, All rights reserved.