Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9

被引：76

作者：

Chen, Pu ^{[1
]}

Lu, Na ^{[1
]}

Ling, Yun ^{[1
]}

Chen, Yan ^{[1
]}

Hui, Hui ^{[1
]}

Lu, Zhijian ^{[1
]}

Song, Xiuming ^{[1
]}

Li, Zhiyu ^{[1
]}

You, Qidong ^{[1
]}

Guo, Qinglong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Jiangsu Key Lab Carcinogenesis & Intervent, Nanjing 210009, Peoples R China

来源：

TOXICOLOGY | 2011年 / 282卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Wogonin; Invasion; ERK1/2; MMP-9; PKC delta; MATRIX METALLOPROTEINASES; GENE-EXPRESSION; SIGNALING PATHWAY; CANCER CELLS; IN-VIVO; KINASE; ACTIVATION; ACID; ANGIOGENESIS; INVOLVEMENT;

D O I：

10.1016/j.tox.2011.01.018

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Wogonin, a naturally occurring monoflavonoid extracted from Scutellariae radix, has been shown to possess tumor therapeutic potential in vitro and in vivo. However, the effects of wogonin on tumor cells invasion remains poorly understood. In this study, we performed in vitro experiments to investigate the anti-invasive and anti-metastatic activity of wogonin in MDA-MB-231 human breast carcinoma cells. Wogonin caused a concentration-dependent suppression of cell migration, adhesion and invasion. The mechanism revealed that wogonin significantly inhibited the expression and activity of both endogenous and phorbol-12-myristate-13-acetate (PMA)-induced matrix metalloproteinase-9 (MMP-9) potentially associating with the suppression of translocation of protein kinase C (PKC) delta and phosphorylation of extracellular signal-regulated kinase (ERK1/2). These results suggested that wogonin could inhibit the invasion of tumor cells by downregulating the expression and activity of MMP-9. the possible targets may be PKC delta and ERK1/2. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：122 / 128

页数：7

共 32 条

[1]

Matrix metalloproteinases in cancer: comparison of known and novel aspects of their inhibition as a therapeutic approach [J].