Tissue engineering strategies to study cartilage development, degeneration and regeneration

被引：121

作者：

Bhattacharjee, Maumita ^{[1
]}

Coburn, Jeannine ^{[2
]}

Centola, Matteo ^{[3
,4
]}

Murab, Sumit ^{[1
]}

Barbero, Andrea ^{[3
,4
]}

Kaplan, David L. ^{[2
]}

Martin, Ivan ^{[3
,4
]}

Ghosh, Sourabh ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Text Technol, New Delhi 110016, India

[2] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

[3] Univ Basel, Univ Basel Hosp, Dept Surg, CH-4031 Basel, Switzerland

[4] Univ Basel, Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2015年 / 84卷

关键词：

Cartilage tissue; Developmental biology; Scaffolds; Signals; Drug targets; In vitro models; MESENCHYMAL STEM-CELLS; HUMAN ARTICULAR CHONDROCYTES; FORMATION IN-VITRO; MICROCARRIERS ENHANCES REDIFFERENTIATION; CHONDROGENIC PROGENITOR CELLS; OSTEOARTHRITIS-LIKE CHANGES; TRANSCRIPTION FACTOR ERG; SYNOVIAL JOINT FORMATION; HUMAN SEPTAL CARTILAGE; NECROSIS-FACTOR-ALPHA;

D O I：

10.1016/j.addr.2014.08.010

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：107 / 122

页数：16

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