A peptide flavoprotein mimic:: Flavin recognition and redox potential modulation in water by a designed β hairpin

被引：34

作者：

Butterfield, SM

Goodman, CM

Rotello, VM

Waters, ML

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ Massachusetts, Dept Chem, Dept Polymer Sci & Engn, Cell & Mol Biol Program, Amherst, MA 01003 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 06期

关键词：

D O I：

10.1002/anie.200352527

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pinning down flavoproteins: A designed β-hairpin peptide binds flavin mononucleotide (FMN) in water through noncovalent interactions involving Trp and Lys residues on one face of the β hairpin (see model). Reduction of FMN is disfavored in the complex as a result of favorable π-π stacking interactions between Trp side chains and the oxidized flavin ring. This system mimicks the function of naturally occurring flavoproteins.

引用

页码：724 / 727

页数：4

共 29 条

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[Anonymous], [No title captured]

[2]

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