Harnessing the Mesenchymal Stem Cell Secretome for the Treatment of Cardiovascular Disease

被引：685

作者：

Ranganath, Sudhir H. ^{[1
,2
,3
,4
,5
,6
]}

Levy, Oren ^{[2
,3
,4
,5
]}

Inamdar, Maneesha S. ^{[1
,6
]}

Karp, Jeffrey M. ^{[2
,3
,4
,5
]}

机构：

[1] Jawaharlal Nehru Ctr Adv Sci Res, Bangalore 560064, Karnataka, India

[2] Harvard Univ, Brigham & Womens Hosp, Ctr Regenerat Therapeut, Sch Med, Cambridge, MA 02139 USA

[3] Harvard Univ, Brigham & Womens Hosp, Dept Med, Sch Med, Cambridge, MA 02139 USA

[4] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[6] GKVK, Inst Stem Cell Biol & Regenerat Med, Natl Ctr Biol Sci, Bangalore 560065, Karnataka, India

来源：

CELL STEM CELL | 2012年 / 10卷 / 03期

关键词：

ENDOTHELIAL GROWTH-FACTOR; COLONY-STIMULATING FACTOR; ELEVATION MYOCARDIAL-INFARCTION; CARDIAC PROGENITOR CELLS; BONE-MARROW; STROMAL CELLS; HEART-FAILURE; RAT MODEL; FACTOR-I; PARACRINE MECHANISMS;

D O I：

10.1016/j.stem.2012.02.005

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplantation. This review outlines the current understanding of the MSC secretome as a therapeutic for treatment of ischemic heart disease. We discuss ongoing investigative directions aimed at improving cellular activity and characterizing the secretome and its regulation in greater detail. Finally, we provide insights on and perspectives for future development of the MSC secretome as a therapeutic tool.

引用

页码：244 / 258

页数：15

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