Lipoic acid improves survival in transgenic mouse models of Huntington's disease

被引：89

作者：

Andreassen, OA

Ferrante, RJ

Dedeoglu, A

Beal, MF

机构：

[1] Cornell Univ, Weill Med Coll, New York Hosp, Cornell Med Ctr,Dept Neurol & Neurosci, New York, NY 10021 USA

[2] Massachusetts Gen Hosp, Neurol Serv, Neurochem Lab, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Bedford VA Med Ctr, Ctr Geriatr Res Educ & Clin, Bedford, MA USA

[5] Boston Univ, Sch Med, Boston, MA 02118 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 15期

关键词：

antioxidants; excitotoxicity; Huntington's disease; alpha-lipoic acid; transgenic mice;

D O I：

10.1097/00001756-200110290-00044

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenylbutyinitrone (S-PBN) and alpha -lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha -Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha -lipoic acid might have beneficial effects in HD patients. NeuroReport 12:3371-3373 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3371 / 3373

页数：3

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