Anti-inflammatory action of alpha-melanocyte stimulating hormone (α-MSH) in anti-CD3/CD28-mediated spleen and CD4+CD25- T cells and a partial participation of IL-10

被引：6

作者：

Chang, Sung Ho ^{[1
,2
,3
]}

Jung, Eun Jung ^{[1
,2
,3
]}

Lim, Dong Gyun ^{[1
,2
,3
]}

Park, Youn Hee ^{[1
,2
,3
]}

Wee, Yu Mee ^{[1
,2
,3
]}

Kim, Jin Hee ^{[1
,2
,3
]}

Kim, Yang Hee ^{[1
,2
,3
]}

Choi, Monica Young ^{[1
,2
,3
]}

Koo, Sun Kyung ^{[1
,2
,3
]}

Choi, Kang Duk ^{[4
]}

Han, Duck Jong ^{[1
,2
,3
]}

Kim, Song Cheol ^{[1
,2
,3
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Surg, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea

[3] Asan Med Ctr, Seoul 138736, South Korea

[4] Hankyong Natl Univ, Gyeong Gi Reg Res Ctr, Ansung City 456749, Gyeonggi Do, South Korea

来源：

IMMUNOLOGY LETTERS | 2008年 / 118卷 / 01期

关键词：

alpha-melanocyte stimulating hormone (alpha-MSH); spleen cells; CD4(+)CD25(-) T cells; anti-CD3/CD28; interleukin 10 (IL-10); anti-IL-10 blocking Ab; interleukin 2 (IL-2); interferon gamma (IFN-gamma);

D O I：

10.1016/j.imlet.2008.02.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

alpha-Melanocyte stimulating hormone (alpha-MSH) has been shown to inhibit the production and the effects of pro-inflammatory cytokine by inflammatory cells in innate immunity. We have determined whether alpha-MSH inhibits anti-CD3/CD28-mediated spleen cells and CD4(+)CD25(-) Tcells proliferation and its mechanism of action. The proliferation of anti-CD3/CD28-mediated spleen cells and CD4(+)CD25(-) Tcells markedly were suppressed by 50-100 nM and 5-100 nM alpha-MSH, respectively. alpha-MSH (100 nM) increased the production of the anti-inflammatory cytokine IL-10 and decreased the production of the pro-inflammatory cytokine IL-2 and IFN-gamma from CD4(+)CD25(-) Tcells. Moreover, anti-IL-10 blocking Ab decreased the inhibitory effects of anti-CD3/CD28-mediated spleen cells and CD4(+)CD25(-) Tcells proliferation by alpha-MSH, indicating a partial participation of IL-10 in its mechanism of inhibitory action. These results suggest that alpha-MSH may be useful for treatment of autoimmune diseases and transplantation involving innate and adaptive immunity. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：44 / 48

页数：5

共 33 条

[1]

Arakelov A, 2000, SEMIN NEPHROL, V20, P95

[2]

HIGH-LEVELS OF INTERLEUKIN-10 PRODUCTION IN-VIVO ARE ASSOCIATED WITH TOLERANCE IN SCID PATIENTS TRANSPLANTED WITH HLA MISMATCHED HEMATOPOIETIC STEM-CELLS [J].