Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat

被引：13

作者：

Hillefors, M

von Euler, M

Hedlund, PB

von Euler, G ^{[1
]}

机构：

[1] Karolinska Hosp, Karolinska Inst, Dept Clin Neurosci, Neurosurg Sect, S-17176 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden

[3] Huddinge Hosp, Karolinska Inst, Dept Clin Neurosci & Family Med, Div Geriatr Med, S-14157 Huddinge, Sweden

来源：

BRAIN RESEARCH | 1999年 / 822卷 / 1-2期

关键词：

PD; 128907; dopamine D-3 receptor; binding affinity; basal ganglia; caudate-putamen; islands of Calleja;

D O I：

10.1016/S0006-8993(99)01138-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have analyzed the binding properties of the selective D-3 receptor agonist [H-3]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [H-3]PD 128907 bath in the islands of Calleja and the caudate-putamen (B-max values being 500 and 1000 fmol/mg protein, respectively). The K-D values were higher in the caudate-putamen than in the islands of Calleja. Similar regional differences in B-max and K-D values were observed in membranes from the caudate-putamen and the subcortical limbic region. The distribution of [H-3]PD 128907 in adult rats is markedly different from that observed in young rats. Taken together, the present results suggest a prominent presence of D-3 receptors in the caudate-putamen of adult, but not young, rats. Hence, these findings may have important physiological, pathophysiological, and clinical implications. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：126 / 131

页数：6

共 29 条

[1] CHARACTERIZATION OF BINDING OF [H-3]PD-128907, A SELECTIVE DOPAMINE D-3 RECEPTOR AGONIST LIGAND, TO CHO-K1 CELLS [J].