Polyphenol-rich seaweed (Eucheuma cottonii) extract suppresses breast tumour via hormone modulation and apoptosis induction

被引：115

作者：

Namvar, Farideh ^{[1
,6
]}

Mohamed, Suhaila ^{[1
]}

Fard, Samaneh Ghasemi ^{[1
]}

Behravan, Javad ^{[5
]}

Mustapha, Noordin M. ^{[2
]}

Alitheen, Noorjahan Banu M. ^{[3
]}

Othman, Fauziah ^{[4
]}

机构：

[1] Univ Putra Malaysia, Fac Food Sci & Technol, Inst Biosci IBS UPM, Serdang 43444, Selangor, Malaysia

[2] Univ Putra Malaysia, Fac Vet Med, Serdang 43444, Selangor, Malaysia

[3] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Serdang 43444, Selangor, Malaysia

[4] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang 43444, Selangor, Malaysia

[5] Mashhad Univ Med Sci, Sch Pharm, Miotechnol Res Ctr, Mshhad, Iran

[6] Islamic Azad Univ Med Sci, Fac Med, Mashhad, Iran

来源：

FOOD CHEMISTRY | 2012年 / 130卷 / 02期

关键词：

Antioxidant enzymes; Breast neoplasm; Anti-oestrogen; Seaweed; Apoptosis; BROWN; ANTIOXIDANT; JAPANESE; IODINE; COLON; WOMEN;

D O I：

10.1016/j.foodchem.2011.07.054

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The edible red seaweed Eucheuma cottonii is abundantly cultivated for carrageenan production. This study investigated the effects of dietary E. cottonii polyphenol-rich extract (ECME) on breast cancer. In vitro assays showed that ECME was antiproliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells (IC50 values of 20 and 42 mu g/ml, respectively) but was non-toxic to normal cell lines. The ECME (150 and 300 mg/kg BW) was fed to female rats and, after 4 weeks, rat mammary tumour was induced using LA7 cells (inoculated subcutaneously). The ECME inhibited tumour development and erythrocyte lipid peroxidation in the cancer-induced rats, dose-dependently. It showed anti-oestrogenic effects on the rat estrous cycle and serum hormone levels. Electron microscopy and histopathology observations confirmed apoptosis in the rat mammary tumours. The polyphenol-rich ECME was tumour-suppressive via apoptosis induction, downregulating the endogenous oestrogen biosynthesis, and improving antioxidative status in the rats. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：376 / 382

页数：7

共 30 条

[1]

Is iodine a gatekeeper of the integrity of the mammary gland? [J].