Factors controlling the turnover of T memory cells

被引:71
作者
Sprent, J
Tough, DF
Sun, SQ
机构
[1] Department of Immunology, Scripps Research Institute, San Diego, CA
[2] Department of Immunology, IMM4, Scripps Research Institute, San Diego, CA 92037
关键词
D O I
10.1111/j.1600-065X.1997.tb00960.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Most of the T cells participating in the primary immune response are rapidly eliminated, but small numbers of these cells survive and differentiate into long-lived memory cells. Information on the life history of memory cells can be obtained by studying the component of memory-phenotype T cells found in normal animals; these cells are presumed to represent memory cells specific for various environmental antigens. For CD8(+) cells, in vivo exposure to viruses and certain other infectious agents causes a large proportion of memory-phenotype (CD44(hi)) cells to enter the cell cycle. In this situation, stimulation of CD44(hi) CD8(+) cells does not seem to require T-cell receptor ligation and appears to reflect release of various cytokines, especially type I interferon. The capacity of infectious agents to induce non-antigen-specific stimulation of T cells may play a role in boosting the survival of memory cells and perhaps also in providing an adjuvant function during the primary response.
引用
收藏
页码:79 / 85
页数:7
相关论文
共 57 条
[1]   THE SIGNIFICANCE OF LOW BCL-2 EXPRESSION BY CD45RO-T-CELLS IN NORMAL INDIVIDUALS AND PATIENTS WITH ACUTE VIRAL-INFECTIONS - THE ROLE OF APOPTOSIS IN T-CELL MEMORY [J].
AKBAR, AN ;
BORTHWICK, N ;
SALMON, M ;
GOMBERT, W ;
BOFILL, M ;
SHAMSADEEN, N ;
PILLING, D ;
PETT, S ;
GRUNDY, JE ;
JANOSSY, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :427-438
[2]   INTERCONVERSION OF CD45R SUBSETS OF CD4 T-CELLS INVIVO [J].
BELL, EB ;
SPARSHOTT, SM .
NATURE, 1990, 348 (6297) :163-166
[3]  
Beverley P C, 1992, Semin Immunol, V4, P35
[4]   IS T-CELL MEMORY MAINTAINED BY CROSS-REACTIVE STIMULATION [J].
BEVERLEY, PCL .
IMMUNOLOGY TODAY, 1990, 11 (06) :203-205
[5]   VARIABLE PATTERNS OF TOTAL DNA AND RDNA METHYLATION IN ANIMALS [J].
BIRD, AP ;
TAGGART, MH .
NUCLEIC ACIDS RESEARCH, 1980, 8 (07) :1485-1497
[6]   EFFECTS OF IL-12 ON IMMUNE-RESPONSES TO MICROBIAL INFECTIONS - A KEY MEDIATOR IN REGULATING DISEASE OUTCOME [J].
BIRON, CA ;
GAZZINELLI, RT .
CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (04) :485-496
[7]   CD28 COSTIMULATION CAN PROMOTE T-CELL SURVIVAL BY ENHANCING THE EXPRESSION OF BCL-X(L) [J].
BOISE, LH ;
MINN, AJ ;
NOEL, PJ ;
JUNE, CH ;
ACCAVITTI, MA ;
LINDSTEN, T ;
THOMPSON, CB .
IMMUNITY, 1995, 3 (01) :87-98
[8]  
Buchmeier M J, 1980, Adv Immunol, V30, P275, DOI 10.1016/S0065-2776(08)60197-2
[9]  
BUDD RC, 1987, J IMMUNOL, V138, P3120
[10]   THE CELLULAR BASIS OF T-CELL MEMORY [J].
CEROTTINI, JC ;
MACDONALD, HR .
ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :77-89