Immunopathogenesis of inflammatory bowel disease

被引：203

作者：

Shih, David Q. ^{[1
,2
]}

Targan, Stephan R. ^{[1
]}

机构：

[1] Cedars Sinai Inflammat Bowel Dis Ctr, Los Angeles, CA 90048 USA

[2] Univ Calif Los Angeles, Div Digest Dis, Los Angeles, CA USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 03期

关键词：

Crohn's disease; ulcerative colitis; Innate and adaptive immune system;

D O I：

10.3748/wjg.14.390

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Crohn's disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn's disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. (c) 2008 WJG. All rights reserved.

引用

页码：390 / 400

页数：11

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