Tau genotype: No effect on onset, symptom severity, or survival in progressive supranuclear palsy

被引：24

作者：

Litvan, I

Baker, M

Hutton, M

机构：

[1] Henry M Jackson Fdn, Cognit Neuropharmacol Unit, Bethesda, MD 20817 USA

[2] Mayo Clin Jacksonville, Jacksonville, FL 32224 USA

来源：

NEUROLOGY | 2001年 / 57卷 / 01期

关键词：

D O I：

10.1212/WNL.57.1.138

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Genetic studies have shown that progressive supranuclear palsy (PSP) is associated with inheritance of a specific genotype (H1/H1) in the tau gene. The authors investigated whether the H1/H1 genotype or A0/A0 genotype independently or in conjunction with selected environmental risk factors influences the age at onset, severity, or survival in patients with PSP. Our findings suggest that tau genotyping does not predict the prognosis of PSP.

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页码：138 / 140

页数：3

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