Trefoil factor family 2 deficiency and immune response

被引：58

作者：

Baus-Loncar, M

Kayademir, T

Takaishi, S

Wang, T

机构：

[1] JJ Strossmayer Univ, Sch Med, Dept Biol, Osijek 31000, Croatia

[2] Univ Tubingen, Dept Mol Genet, D-71074 Tubingen, Germany

[3] Columbia Univ Coll Phys & Surg, Dept Med, Div Digest & Liver Dis, New York, NY 10032 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2005年 / 62卷 / 24期

关键词：

TFF2; gastrointestinal defense; deficiency; gene expression; immune response;

D O I：

10.1007/s00018-005-5483-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protective effect of Trefoil Factor Family (TFF) proteins in the gastrointestinal tract by promoting the healing of injured mucosa is well known. An increasing body of evidence connects TFFs, especially, TFF2 and TFF3, with a possible role in immune regulation. TFF2 is able to inhibit lipopolysaccharide-induced nitric oxide production in monocytes and can potently limit leukocyte recruitment at the site of injury. An analysis of gene expression in gastrointestinal tissue of TFF2-deficient mice reveals some new aspects of TFF2's role in the immune response.

引用

收藏

页码：2947 / 2955

页数：9

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