Marine toxins as sources of drug leads

被引：13

作者：

Alewood, P ^{[1
]}

Hopping, G ^{[1
]}

Armishaw, C ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2003年 / 56卷 / 08期

关键词：

D O I：

10.1071/CH03043

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conotoxins, a class of marine peptides rich in disulfide bonds, contain many of the structural elements present in larger proteins, such as α-helices and β-turns. In addition, these natural products are remarkably stable and exhibit exceptional receptor selectivity. These properties make them ideal candidates for drug development.

引用

页码：769 / 774

页数：6

共 28 条

[1]

Adams DJ, 1999, DRUG DEVELOP RES, V46, P219

[2] PEPTIDE-SYNTHESIS .7. SOLID-PHASE SYNTHESIS OF CONOTOXIN-G1 [J].

ATHERTON, E ;

SHEPPARD, RC ;

WARD, P .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (10) :2065-2073

[3] Leu10 of α-conotoxin PnIB confers potency for neuronal nicotinic responses in bovine chromaffin cells [J].

Broxton, N ;

Miranda, L ;

Gehrmann, J ;

Down, J ;

Alewood, P ;

Livett, B .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 390 (03) :229-236

[4]

Cox B, 2000, Curr Rev Pain, V4, P488

[5] Post-translationally modified neuropeptides from Conus venoms [J].

Craig, AG ;

Bandyopadhyay, P ;

Olivera, BM .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (02) :271-275

[6] HIGH-RESOLUTION EPITOPE MAPPING OF HGH-RECEPTOR INTERACTIONS BY ALANINE-SCANNING MUTAGENESIS [J].

CUNNINGHAM, BC ;

WELLS, JA .

SCIENCE, 1989, 244 (4908) :1081-1085

[7] Overview of nicotinic receptors and their roles in the central nervous system [J].

Dani, JA .

BIOLOGICAL PSYCHIATRY, 2001, 49 (03) :166-174

[8] A new level of conotoxin diversity, a non-native disulfide bond connectivity in α-conotoxin AuIB reduces structural definition but increases biological activity [J].

Dutton, JL ;

Bansal, PS ;

Hogg, RC ;

Adams, DJ ;

Alewood, PF ;

Craik, DJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (50) :48849-48857

[9] PHARMACOLOGICAL ACTIONS ON GUINEA-PIG ILEUM OF CRUDE VENOMS FROM MARINE GASTROPODS CONUS-STRIATUS AND CONUS-MAGUS [J].

ENDEAN, R ;

GYR, P ;

SURRIDGE, J .

TOXICON, 1977, 15 (04) :327-337

[10] NEW MOLLUSK-SPECIFIC ALPHA-CONOTOXINS BLOCK APLYSIA NEURONAL ACETYLCHOLINE-RECEPTORS [J].

FAINZILBER, M ;

HASSON, A ;

OREN, R ;

BURLINGAME, AL ;

GORDON, D ;

SPIRA, ME ;

ZLOTKIN, E .

BIOCHEMISTRY, 1994, 33 (32) :9523-9529

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