Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

被引：49

作者：

Bugge, Anne ^{[1
]}

Mandrup, Susanne ^{[1
]}

机构：

[1] Univ So Denmark, Dept Biochem & Mol Biol, DK-5230 Odense, Denmark

来源：

PPAR RESEARCH | 2010年 / 2010卷

关键词：

ACTIVATED-RECEPTOR-GAMMA; RETINOID-X-RECEPTOR; GENE-EXPRESSION; NUCLEAR RECEPTORS; ADIPOCYTE DIFFERENTIATION; LIGAND-BINDING; ADIPOSE-TISSUE; TARGET GENES; FATTY-ACIDS; MOUSE-LIVER;

D O I：

10.1155/2010/169506

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR alpha, alpha/beta, and gamma activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.

引用

页数：12

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