Changing Face of Microglia

被引：513

作者：

Graeber, Manuel B. ^{[1
]}

机构：

[1] Univ Sydney, Brain & Mind Res Inst, Camperdown, NSW 2050, Australia

来源：

SCIENCE | 2010年 / 330卷 / 6005期

关键词：

MARROW-DERIVED MICROGLIA; PERIVASCULAR CELLS; NEURONAL DEATH; IN-VIVO; ACTIVATION; EXPRESSION; CNS; DAP12; INVOLVEMENT; SYNAPSES;

D O I：

10.1126/science.1190929

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Microglia are resident brain cells that sense pathological tissue alterations. They can develop into brain macrophages and perform immunological functions. However, expression of immune proteins by microglia is not synonymous with inflammation, because these molecules can have central nervous system (CNS)-specific roles. Through their involvement in pain mechanisms, microglia also respond to external threats. Experimental studies support the idea that microglia have a role in the maintenance of synaptic integrity. Analogous to electricians, they are capable of removing defunct axon terminals, thereby helping neuronal connections to stay intact. Microglia in healthy CNS tissue do not qualify as macrophages, and their specific functions are beginning to be explored.

引用

页码：783 / 788

页数：6

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